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I've not read A New Kind of Science; I will check it out.
The Origins of Order, and the later Investigations changed my perspective. Its not often a book can do that. One of the only other books that has affected me so profoundly was Philosophic Investigations, which, perhaps not coincidentally, is where Kauffman took his title from (because he was trying to do for biology what Wittgenstein did for philosophy and lingustics, which is, prove that irreducible levels of order exist that can't be understood in any kind of atomized way). Regardless of the findings of the Santa Fe Institute, Kauffman is an intellectual heavyweight.